BDBM153660 US8999998, 51

SMILES: Clc1ccccc1-n1nccc1NC(=O)c1cnn2cccnc12

InChI Key: InChIKey=CHPDJDGBCILPAW-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 153660   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM153660 (US8999998, 51) Show SMILES Clc1ccccc1-n1nccc1NC(=O)c1cnn2cccnc12 Show InChI InChI=1S/C16H11ClN6O/c17-12-4-1-2-5-13(12)23-14(6-8-19-23)21-16(24)11-10-20-22-9-3-7-18-15(11)22/h1-10H,(H,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	15.2	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...				US Patent US8999998 (2015) BindingDB Entry DOI: 10.7270/Q2J67FN6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM153660 (US8999998, 51) Show SMILES Clc1ccccc1-n1nccc1NC(=O)c1cnn2cccnc12 Show InChI InChI=1S/C16H11ClN6O/c17-12-4-1-2-5-13(12)23-14(6-8-19-23)21-16(24)11-10-20-22-9-3-7-18-15(11)22/h1-10H,(H,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	83.7	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...				US Patent US8999998 (2015) BindingDB Entry DOI: 10.7270/Q2J67FN6
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM153660 (US8999998, 51) Show SMILES Clc1ccccc1-n1nccc1NC(=O)c1cnn2cccnc12 Show InChI InChI=1S/C16H11ClN6O/c17-12-4-1-2-5-13(12)23-14(6-8-19-23)21-16(24)11-10-20-22-9-3-7-18-15(11)22/h1-10H,(H,21,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	98	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated JAK1, JAK2 or TYK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-Ala-Leu-...				US Patent US8999998 (2015) BindingDB Entry DOI: 10.7270/Q2J67FN6
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM153660 (US8999998, 51) Show SMILES Clc1ccccc1-n1nccc1NC(=O)c1cnn2cccnc12 Show InChI InChI=1S/C16H11ClN6O/c17-12-4-1-2-5-13(12)23-14(6-8-19-23)21-16(24)11-10-20-22-9-3-7-18-15(11)22/h1-10H,(H,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	150	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The activity of the isolated JAK3 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Leu-Pro-Leu-Asp-Lys-Asp-Ty...				US Patent US8999998 (2015) BindingDB Entry DOI: 10.7270/Q2J67FN6
					More data for this Ligand-Target Pair