BDBM153709 7-(4-methylphenyl)-5-phenyl-N-(thiophen-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (8a)

SMILES: Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3cccs3)ncnc12

InChI Key: InChIKey=WSJRRWAQNGSBBL-UHFFFAOYSA-N

Data: 1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153709   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) (Homo sapiens (Human))	BDBM153709 (7-(4-methylphenyl)-5-phenyl-N-(thiophen-2-ylmethyl...) Show SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3cccs3)ncnc12 Show InChI InChI=1S/C24H20N4S/c1-17-9-11-19(12-10-17)28-15-21(18-6-3-2-4-7-18)22-23(26-16-27-24(22)28)25-14-20-8-5-13-29-20/h2-13,15-16H,14H2,1H3,(H,25,26,27)	PDB B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	7.4	n/a
Technische Universität Dortmund					Assay Description Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...				ACS Chem Biol 10: 279-88 (2015) Article DOI: 10.1021/cb500355c BindingDB Entry DOI: 10.7270/Q218358G
					More data for this Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) (Homo sapiens (Human))	BDBM153709 (7-(4-methylphenyl)-5-phenyl-N-(thiophen-2-ylmethyl...) Show SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3cccs3)ncnc12 Show InChI InChI=1S/C24H20N4S/c1-17-9-11-19(12-10-17)28-15-21(18-6-3-2-4-7-18)22-23(26-16-27-24(22)28)25-14-20-8-5-13-29-20/h2-13,15-16H,14H2,1H3,(H,25,26,27)	PDB B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.96E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universität Dortmund					Assay Description IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...				ACS Chem Biol 10: 279-88 (2015) Article DOI: 10.1021/cb500355c BindingDB Entry DOI: 10.7270/Q218358G
					More data for this Ligand-Target Pair