BDBM153717 N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-(3-nitrophenoxy)pyrimidin-4-amine (14)

SMILES: CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Oc2cccc(c2)[N+]([O-])=O)n1

InChI Key: InChIKey=HZKIIUFULFKKEU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153717   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM153717 (N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Oc2cccc(c2)[N+]([O-])=O)n1 Show InChI InChI=1S/C19H22N8O3/c1-13-10-17(24-23-13)20-16-12-18(26-8-6-25(2)7-9-26)22-19(21-16)30-15-5-3-4-14(11-15)27(28)29/h3-5,10-12H,6-9H2,1-2H3,(H2,20,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TU Dortmund University Curated by ChEMBL					Assay Description Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-...				J Med Chem 58: 6844-63 (2015) BindingDB Entry DOI: 10.7270/Q2WM1G59
					More data for this Ligand-Target Pair
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM153717 (N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Oc2cccc(c2)[N+]([O-])=O)n1 Show InChI InChI=1S/C19H22N8O3/c1-13-10-17(24-23-13)20-16-12-18(26-8-6-25(2)7-9-26)22-19(21-16)30-15-5-3-4-14(11-15)27(28)29/h3-5,10-12H,6-9H2,1-2H3,(H2,20,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technical University of Dortmund					Assay Description IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...				ACS Chem Biol 10: 289-98 (2015) Article DOI: 10.1021/cb500908d BindingDB Entry DOI: 10.7270/Q2WH2NRB
					More data for this Ligand-Target Pair