new BindingDB logo
myBDB logout

BDBM155348 US9006268, 19

SMILES: Fc1ccc(cc1)-c1nc(c(o1)C1CCN(CCc2ccccc2)CC1)-c1ncccn1

InChI Key: InChIKey=ULSJKZIHGJPJNY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 155348   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolylcarboxypeptidase (PRCP)


(Homo sapiens (Human))
BDBM155348
PNG
(US9006268, 19)
Show SMILES Fc1ccc(cc1)-c1nc(c(o1)C1CCN(CCc2ccccc2)CC1)-c1ncccn1
Show InChI InChI=1S/C26H25FN4O/c27-22-9-7-21(8-10-22)26-30-23(25-28-14-4-15-29-25)24(32-26)20-12-17-31(18-13-20)16-11-19-5-2-1-3-6-19/h1-10,14-15,20H,11-13,16-18H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.780n/an/an/an/a5.5n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The assay was run in a 384-well microtiter plate at 37° C. with a total volume of 50 uL. Final assay concentrations were 0.13 nM human PrCP (CHO) or...


US Patent US9006268 (2015)


BindingDB Entry DOI: 10.7270/Q2J38R9S
More data for this
Ligand-Target Pair