BDBM155448 US9006454, I90

SMILES: Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1ccc(cc1)-c1ccc(NC(=O)C2CCNCC2)cc1

InChI Key: InChIKey=YRUJWAVORLHXJV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 155448   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (Homo sapiens (Human))	BDBM155448 (US9006454, I90) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1ccc(cc1)-c1ccc(NC(=O)C2CCNCC2)cc1 Show InChI InChI=1S/C27H26N4O3/c1-16-14-22(27(33)34)24-23(15-16)30-25(31-24)19-4-2-17(3-5-19)18-6-8-21(9-7-18)29-26(32)20-10-12-28-13-11-20/h2-9,14-15,20,28H,10-13H2,1H3,(H,29,32)(H,30,31)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.69E+3	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair