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BDBM156307 US9018217, 6-Chloro-8-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-ylsulfanylmethyl)-imidazo[1,2-a]pyridine::US9592230, 6-Chloro-8-methyl-2-(1-methyl-4-phenyl-1H-imidazol-2-ylsulfanylmethyl)-imidazo[1,2-a]pyridine

SMILES: Cc1cc(Cl)cn2cc(CSc3nc(cn3C)-c3ccccc3)nc12

InChI Key: InChIKey=BFKWNRUJDWGNAH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 156307   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156307
PNG
(US9018217, 6-Chloro-8-methyl-2-(1-methyl-4-phenyl-...)
Show SMILES Cc1cc(Cl)cn2cc(CSc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C19H17ClN4S/c1-13-8-15(20)9-24-10-16(21-18(13)24)12-25-19-22-17(11-23(19)2)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
PDB
MMDB

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PC cid
PC sid
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Similars

US Patent
n/an/a 890n/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9592230 (2017)


BindingDB Entry DOI: 10.7270/Q2CV4KSH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM156307
PNG
(US9018217, 6-Chloro-8-methyl-2-(1-methyl-4-phenyl-...)
Show SMILES Cc1cc(Cl)cn2cc(CSc3nc(cn3C)-c3ccccc3)nc12
Show InChI InChI=1S/C19H17ClN4S/c1-13-8-15(20)9-24-10-16(21-18(13)24)12-25-19-22-17(11-23(19)2)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 890n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...


US Patent US9018217 (2015)


BindingDB Entry DOI: 10.7270/Q2KW5DS1
More data for this
Ligand-Target Pair