BDBM1575 2-cyclopropyl-9-methyl-5-(pyridin-4-yl)-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one::Dipyridodiazepinone deriv. 68

SMILES: CN1c2ccc(nc2N(C2CC2)c2ncccc2C1=O)-c1ccncc1

InChI Key: InChIKey=MWENNCGXKSSEBF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 1575   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase Mutant (Y181C) (Human immunodeficiency virus type 1)	BDBM1575 (2-cyclopropyl-9-methyl-5-(pyridin-4-yl)-2,4,9,15-t...) Show SMILES CN1c2ccc(nc2N(C2CC2)c2ncccc2C1=O)-c1ccncc1 Show InChI InChI=1S/C20H17N5O/c1-24-17-7-6-16(13-8-11-21-12-9-13)23-19(17)25(14-4-5-14)18-15(20(24)26)3-2-10-22-18/h2-3,6-12,14H,4-5H2,1H3	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 38: 4830-8 (1995) Article DOI: 10.1021/jm00024a010 BindingDB Entry DOI: 10.7270/Q23B5XBJ
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1575 (2-cyclopropyl-9-methyl-5-(pyridin-4-yl)-2,4,9,15-t...) Show SMILES CN1c2ccc(nc2N(C2CC2)c2ncccc2C1=O)-c1ccncc1 Show InChI InChI=1S/C20H17N5O/c1-24-17-7-6-16(13-8-11-21-12-9-13)23-19(17)25(14-4-5-14)18-15(20(24)26)3-2-10-22-18/h2-3,6-12,14H,4-5H2,1H3	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 38: 4830-8 (1995) Article DOI: 10.1021/jm00024a010 BindingDB Entry DOI: 10.7270/Q23B5XBJ
					More data for this Ligand-Target Pair