BDBM15847 2-carboxyindole-based inhibitor 32::5-(5-chlorothiophen-2-yl)-3-[(2-{[4-(pyridin-4-yloxy)piperidin-1-yl]carbonyl}-1H-indol-1-yl)methyl]-1,2-oxazole

SMILES: Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)N2CCC(CC2)Oc2ccncc2)no1

InChI Key: InChIKey=UPZFSDPZCQPKHL-UHFFFAOYSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor X (Homo sapiens (Human))	BDBM15847 (2-carboxyindole-based inhibitor 32 | 5-(5-chloroth...) Show SMILES Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)N2CCC(CC2)Oc2ccncc2)no1 Show InChI InChI=1S/C27H23ClN4O3S/c28-26-6-5-25(36-26)24-16-19(30-35-24)17-32-22-4-2-1-3-18(22)15-23(32)27(33)31-13-9-21(10-14-31)34-20-7-11-29-12-8-20/h1-8,11-12,15-16,21H,9-10,13-14,17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aventis Pharma Deutschland GmbH					Assay Description The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...				Bioorg Med Chem Lett 14: 4197-201 (2004) Article DOI: 10.1016/j.bmcl.2004.06.019 BindingDB Entry DOI: 10.7270/Q2610XKM
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