BDBM158704 US9034866, 179
SMILES: CC(C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O
InChI Key: InChIKey=QXYJIAHKEQMAPH-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human)) | BDBM158704 (US9034866, 179) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of NIK (unknown origin) after 1 to 2 hrs by ADP-FP assay | J Med Chem 60: 627-640 (2017) Article DOI: 10.1021/acs.jmedchem.6b01363 BindingDB Entry DOI: 10.7270/Q2K35X4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human)) | BDBM158704 (US9034866, 179) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 22 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
Genentech, Inc. US Patent | Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u... | US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphoinositide 3-Kinase (PI3K), delta (Homo sapiens (Human)) | BDBM158704 (US9034866, 179) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged recombinant full-length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus... | J Med Chem 60: 627-640 (2017) Article DOI: 10.1021/acs.jmedchem.6b01363 BindingDB Entry DOI: 10.7270/Q2K35X4S | |||||||||||
More data for this Ligand-Target Pair |