Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 14' and Ligand = 'BDBM158704'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM158704 (US9034866, 179) Show SMILES CC(C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O |(6.19,-.05,;4.85,.72,;6.19,1.49,;4.85,2.26,;3.52,-.05,;2.18,-.82,;.85,-1.59,;.85,-3.13,;-.48,-3.9,;-1.82,-3.13,;-3.02,-4.09,;-4.52,-3.75,;-5.19,-2.36,;-3.58,-2.59,;-4.52,-.97,;-5.31,.35,;-4.3,1.51,;-2.88,.91,;-3.02,-.63,;-1.82,-1.59,;-.48,-.82,;-4.7,3,;-3.61,4.09,;-6.19,3.4,)| Show InChI InChI=1S/C19H19N3O2/c1-19(2,24)6-5-11-3-4-14-12-8-13(9-12)22-10-16(17(20)23)21-18(22)15(14)7-11/h3-4,7,10,12-13,24H,8-9H2,1-2H3,(H2,20,23)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of NIK (unknown origin) after 1 to 2 hrs by ADP-FP assay				J Med Chem 60: 627-640 (2017) Article DOI: 10.1021/acs.jmedchem.6b01363 BindingDB Entry DOI: 10.7270/Q2K35X4S
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM158704 (US9034866, 179) Show SMILES CC(C)(O)C#Cc1ccc2C3CC(C3)n3cc(nc3-c2c1)C(N)=O |(6.19,-.05,;4.85,.72,;6.19,1.49,;4.85,2.26,;3.52,-.05,;2.18,-.82,;.85,-1.59,;.85,-3.13,;-.48,-3.9,;-1.82,-3.13,;-3.02,-4.09,;-4.52,-3.75,;-5.19,-2.36,;-3.58,-2.59,;-4.52,-.97,;-5.31,.35,;-4.3,1.51,;-2.88,.91,;-3.02,-.63,;-1.82,-1.59,;-.48,-.82,;-4.7,3,;-3.61,4.09,;-6.19,3.4,)| Show InChI InChI=1S/C19H19N3O2/c1-19(2,24)6-5-11-3-4-14-12-8-13(9-12)22-10-16(17(20)23)21-18(22)15(14)7-11/h3-4,7,10,12-13,24H,8-9H2,1-2H3,(H2,20,23)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	22	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...				US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0
					More data for this Ligand-Target Pair