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BDBM158808 US9034866, 283

SMILES: Cn1c(nc-2c1C1CC(C1)c1cc(F)c(cc-21)C#C[C@@](C)(O)c1ncccn1)C(N)=O

InChI Key: InChIKey=FCHYTOXNLKIWDC-ZUGFLLEASA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 158808   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase kinase kinase 14


(Homo sapiens (Human))		BDBM158808
PNG
(US9034866, 283)
Show SMILES Cn1c(nc-2c1C1CC(C1)c1cc(F)c(cc-21)C#C[C@@](C)(O)c1ncccn1)C(N)=O |r,wU:19.23,wD:19.24,(-6.49,.12,;-5,-.28,;-3.99,.88,;-2.58,.28,;-2.71,-1.25,;-4.22,-1.6,;-4.88,-2.98,;-4.22,-4.37,;-2.71,-4.72,;-3.38,-3.31,;-1.51,-3.75,;-.18,-4.52,;1.16,-3.75,;2.49,-4.52,;1.16,-2.21,;-.18,-1.44,;-1.51,-2.21,;2.49,-1.44,;3.82,-.67,;5.16,.1,;5.93,-1.24,;6.49,-.67,;5.16,1.64,;6.49,2.41,;6.49,3.95,;5.16,4.72,;3.82,3.95,;3.82,2.41,;-4.39,2.37,;-3.3,3.46,;-5.88,2.77,)|
Show InChI InChI=1S/C23H20FN5O2/c1-23(31,22-26-6-3-7-27-22)5-4-12-10-16-15(11-17(12)24)13-8-14(9-13)19-18(16)28-21(20(25)30)29(19)2/h3,6-7,10-11,13-14,31H,8-9H2,1-2H3,(H2,25,30)/t13?,14?,23-/m1/s1
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Similars
US Patent
 0.160n/an/an/an/an/an/a7.2n/a



Genentech, Inc.

US Patent


Assay Description
The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...

US Patent US9034866 (2015)


BindingDB Entry DOI: 10.7270/Q2GX49B0
More data for this
Ligand-Target Pair