BDBM158886 US9034866, 361

SMILES: CNC(=O)c1c(nc2-c3cc(ccc3C3CC(C3)n12)C#CC1(O)CCC1)C(N)=O

InChI Key: InChIKey=LHHYOXUXGSXXIQ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 158886   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM158886 (US9034866, 361) Show SMILES CNC(=O)c1c(nc2-c3cc(ccc3C3CC(C3)n12)C#CC1(O)CCC1)C(N)=O |(-8.06,.06,;-6.57,-.34,;-5.48,.75,;-5.88,2.24,;-3.99,.35,;-2.98,1.51,;-1.56,.91,;-1.7,-.63,;-.5,-1.59,;.84,-.82,;2.17,-1.59,;2.17,-3.13,;.84,-3.9,;-.5,-3.13,;-1.7,-4.09,;-3.2,-3.75,;-3.87,-2.36,;-2.31,-2.65,;-3.2,-.97,;3.5,-.82,;4.84,-.05,;6.17,.72,;4.84,1.49,;7.66,.32,;8.06,1.81,;6.57,2.21,;-3.38,3,;-2.29,4.09,;-4.87,3.4,)| Show InChI InChI=1S/C22H22N4O3/c1-24-21(28)18-17(19(23)27)25-20-16-9-12(5-8-22(29)6-2-7-22)3-4-15(16)13-10-14(11-13)26(18)20/h3-4,9,13-14,29H,2,6-7,10-11H2,1H3,(H2,23,27)(H,24,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...				US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0
					More data for this Ligand-Target Pair