BDBM159096 US9034866, 571::US9034866, 684

SMILES: NC(=O)c1cc2n(n1)-c1cc(ccc1OCC2(F)F)C#C[C@]1(O)CCNC1=O

InChI Key: InChIKey=NSEPDYTYFWLKHT-KRWDZBQOSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 159096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM159096 (US9034866, 571 | US9034866, 684) Show SMILES NC(=O)c1cc2n(n1)-c1cc(ccc1OCC2(F)F)C#C[C@]1(O)CCNC1=O |r| Show InChI InChI=1S/C18H14F2N4O4/c19-18(20)9-28-13-2-1-10(3-4-17(27)5-6-22-16(17)26)7-12(13)24-14(18)8-11(23-24)15(21)25/h1-2,7-8,27H,5-6,9H2,(H2,21,25)(H,22,26)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.330	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...				US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM159096 (US9034866, 571 | US9034866, 684) Show SMILES NC(=O)c1cc2n(n1)-c1cc(ccc1OCC2(F)F)C#C[C@]1(O)CCNC1=O |r| Show InChI InChI=1S/C18H14F2N4O4/c19-18(20)9-28-13-2-1-10(3-4-17(27)5-6-22-16(17)26)7-12(13)24-14(18)8-11(23-24)15(21)25/h1-2,7-8,27H,5-6,9H2,(H2,21,25)(H,22,26)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.960	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...				US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM159096 (US9034866, 571 | US9034866, 684) Show SMILES NC(=O)c1cc2n(n1)-c1cc(ccc1OCC2(F)F)C#C[C@]1(O)CCNC1=O |r| Show InChI InChI=1S/C18H14F2N4O4/c19-18(20)9-28-13-2-1-10(3-4-17(27)5-6-22-16(17)26)7-12(13)24-14(18)8-11(23-24)15(21)25/h1-2,7-8,27H,5-6,9H2,(H2,21,25)(H,22,26)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...				US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0
					More data for this Ligand-Target Pair