BDBM160475 US10093663, Example 26b::US9682968, Example-26a
SMILES: CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Complement factor B (Homo sapiens (Human)) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi... | US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Homo sapiens (Human)) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Novartis AG US Patent | Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi... | US Patent US10093663 (2018) BindingDB Entry DOI: 10.7270/Q2DF6T75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Homo sapiens (Human)) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Novartis AG US Patent | Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi... | US Patent US10093663 (2018) BindingDB Entry DOI: 10.7270/Q2DF6T75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Homo sapiens (Human)) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PubMed | n/a | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Binding affinity to human serine protease factor B by SPR assay | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Homo sapiens (Human)) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human serine protease factor B in human PNH patient derived sample assessed as prevention of erythrocyte lysis | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Homo sapiens (Human)) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati... | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Mus musculus) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ... | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human AP protein factor D | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor B (Homo sapiens (Human)) | BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human serine protease factor B by TR-FRET based competition binding assay | J Med Chem 63: 5697-5722 (2020) | |||||||||||
More data for this Ligand-Target Pair |