BDBM160778 US9682980, 8-Chloro-7-(4-phenylpiperidin-1-yl)-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-b]pyridazine

SMILES: FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1

InChI Key: InChIKey=OLKHXMUGSWRUQF-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 160778   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160778 (US9682980, 8-Chloro-7-(4-phenylpiperidin-1-yl)-3-(...) Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C18H17ClF3N5/c19-16-14(11-23-27-15(10-18(20,21)22)24-25-17(16)27)26-8-6-13(7-9-26)12-4-2-1-3-5-12/h1-5,11,13H,6-10H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	62	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair