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SMILES: COc1c(F)cccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F

InChI Key: InChIKey=BIRRZQIINJYINB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 161004   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 10 subunit alpha


(Rattus norvegicus (Rat))		BDBM161004
PNG
(US9108903, 69)
Show SMILES COc1c(F)cccc1Oc1ccc(cc1C(=O)Nc1ccc(nc1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C21H14F4N2O5/c1-31-18-14(22)3-2-4-17(18)32-16-8-5-11(21(23,24)25)9-13(16)19(28)27-12-6-7-15(20(29)30)26-10-12/h2-10H,1H3,(H,27,28)(H,29,30)
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Similars
US Patent
n/an/a 135n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...

US Patent US9108903 (2015)


BindingDB Entry DOI: 10.7270/Q23J3BP9
More data for this
Ligand-Target Pair