null
SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
InChI Key: InChIKey=DBXJNQABFNNKPN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashi... | US Patent US10813932 (2020) BindingDB Entry DOI: 10.7270/Q2D79FGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cysteine protease ATG4B (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | US Patent US10813932 (2020) BindingDB Entry DOI: 10.7270/Q2D79FGT | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashio... | US Patent US10813932 (2020) BindingDB Entry DOI: 10.7270/Q2D79FGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashio... | US Patent US10813932 (2020) BindingDB Entry DOI: 10.7270/Q2D79FGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level... | US Patent US10813932 (2020) BindingDB Entry DOI: 10.7270/Q2D79FGT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
More data for this Ligand-Target Pair |
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