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BDBM161376 US10238658, Example 1::US10813932, Example 1::US9108950, 1::US9724347, Example 1::US9993478, Example 1
SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccccc3)n2)c2ccccc12)C(C)(C)C
InChI Key: InChIKey=DBXJNQABFNNKPN-UHFFFAOYSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | US Patent US10813932 (2020) | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase HCK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The kinase enzyme binding activities of compounds disclosed herein were determined using a proprietary assay which measures active site-directed comp... | US Patent US9108950 (2015) BindingDB Entry DOI: 10.7270/Q2697293 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase HCK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m... | US Patent US9724347 (2017) BindingDB Entry DOI: 10.7270/Q2MC923K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl | Assay Description p38 MAPKα: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both do... | J Med Chem 52: 5152-63 (2009) BindingDB Entry DOI: 10.7270/Q2125W1Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl | Assay Description p38 MAPKγ: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both do... | J Med Chem 52: 5152-63 (2009) BindingDB Entry DOI: 10.7270/Q2125W1Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl | Assay Description GSK 3α: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both donor... | J Med Chem 52: 5152-63 (2009) BindingDB Entry DOI: 10.7270/Q2125W1Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl | Assay Description c-Src and SyK: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both don... | J Med Chem 52: 5152-63 (2009) BindingDB Entry DOI: 10.7270/Q2125W1Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl | Assay Description c-Src and SyK: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both don... | J Med Chem 52: 5152-63 (2009) BindingDB Entry DOI: 10.7270/Q2125W1Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase HCK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 beta (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation | Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashion to that descr... | J Med Chem 50: 984-1000 (2007) BindingDB Entry DOI: 10.7270/Q2PG1V1T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashi... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashi... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glycogen synthase kinase-3 alpha (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashio... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase SYK (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), were evaluated in a similar fashio... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM161376 (US10238658, Example 1 | US10813932, Example 1 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a |
Respivert Limited US Patent | Assay Description p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det... | US Patent US10813932 (2020) | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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