BDBM161405 US10124003, Ex. Compound 18::US10835536, Ex. Comp 18::US10894048, Ex Comp 18::US9108973, 18

SMILES: COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)(C)C)c2ncnc(N)c12

InChI Key: InChIKey=WYXZTQJCNUKUEX-VOTSOKGWSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 161405   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161405 (US10124003, Ex. Compound 18 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C26H31N7O3/c1-26(2,3)30-10-6-7-22(34)32-14-18(15-32)33-25-23(24(27)28-16-29-25)21(31-33)9-8-17-11-19(35-4)13-20(12-17)36-5/h6-7,11-13,16,18,30H,10,14-15H2,1-5H3,(H2,27,28,29)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.5	25
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US9108973 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HJV
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161405 (US10124003, Ex. Compound 18 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C26H31N7O3/c1-26(2,3)30-10-6-7-22(34)32-14-18(15-32)33-25-23(24(27)28-16-29-25)21(31-33)9-8-17-11-19(35-4)13-20(12-17)36-5/h6-7,11-13,16,18,30H,10,14-15H2,1-5H3,(H2,27,28,29)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10894048 (2021)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161405 (US10124003, Ex. Compound 18 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C26H31N7O3/c1-26(2,3)30-10-6-7-22(34)32-14-18(15-32)33-25-23(24(27)28-16-29-25)21(31-33)9-8-17-11-19(35-4)13-20(12-17)36-5/h6-7,11-13,16,18,30H,10,14-15H2,1-5H3,(H2,27,28,29)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10835536 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161405 (US10124003, Ex. Compound 18 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CNC(C)(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C26H31N7O3/c1-26(2,3)30-10-6-7-22(34)32-14-18(15-32)33-25-23(24(27)28-16-29-25)21(31-33)9-8-17-11-19(35-4)13-20(12-17)36-5/h6-7,11-13,16,18,30H,10,14-15H2,1-5H3,(H2,27,28,29)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10124003 (2018) BindingDB Entry DOI: 10.7270/Q2B27XBQ
					More data for this Ligand-Target Pair