BDBM161407 US10835536, Ex. Comp 20::US10894048, Ex Comp 20::US9108973, 20

SMILES: COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CCCCC2)c2ncnc(N)c12

InChI Key: InChIKey=ZWQCDHDIXJBFQC-VOTSOKGWSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 161407   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161407 (US10835536, Ex. Comp 20 | US10894048, Ex Comp 20 |...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CCCCC2)c2ncnc(N)c12 Show InChI InChI=1S/C27H31N7O3/c1-36-21-13-19(14-22(15-21)37-2)8-9-23-25-26(28)29-18-30-27(25)34(31-23)20-16-33(17-20)24(35)7-6-12-32-10-4-3-5-11-32/h6-7,13-15,18,20H,3-5,10-12,16-17H2,1-2H3,(H2,28,29,30)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.5	25
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US9108973 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HJV
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161407 (US10835536, Ex. Comp 20 | US10894048, Ex Comp 20 |...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CCCCC2)c2ncnc(N)c12 Show InChI InChI=1S/C27H31N7O3/c1-36-21-13-19(14-22(15-21)37-2)8-9-23-25-26(28)29-18-30-27(25)34(31-23)20-16-33(17-20)24(35)7-6-12-32-10-4-3-5-11-32/h6-7,13-15,18,20H,3-5,10-12,16-17H2,1-2H3,(H2,28,29,30)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10894048 (2021)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161407 (US10835536, Ex. Comp 20 | US10894048, Ex Comp 20 |...) Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)\C=C\CN2CCCCC2)c2ncnc(N)c12 Show InChI InChI=1S/C27H31N7O3/c1-36-21-13-19(14-22(15-21)37-2)8-9-23-25-26(28)29-18-30-27(25)34(31-23)20-16-33(17-20)24(35)7-6-12-32-10-4-3-5-11-32/h6-7,13-15,18,20H,3-5,10-12,16-17H2,1-2H3,(H2,28,29,30)/b7-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10835536 (2020)
					More data for this Ligand-Target Pair