BDBM16141 1-guanidino-7-sulfonamidoisoquinoline 15::3-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)-2,2-dimethylpropanoic acid

SMILES: [#6]C([#6])([#6]-[#7]S(=O)(=O)c1ccc2c(Cl)cnc(\[#7]=[#6](/[#7])-[#7])c2c1)[#6](-[#8])=O

InChI Key: InChIKey=AGWMBDOBHRQXEM-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16141   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM16141 (1-guanidino-7-sulfonamidoisoquinoline 15 | 3-({4-c...) Show SMILES [#6]C([#6])([#6]-[#7]S(=O)(=O)c1ccc2c(Cl)cnc(\[#7]=[#6](/[#7])-[#7])c2c1)[#6](-[#8])=O Show InChI InChI=1S/C15H18ClN5O4S/c1-15(2,13(22)23)7-20-26(24,25)8-3-4-9-10(5-8)12(21-14(17)18)19-6-11(9)16/h3-6,20H,7H2,1-2H3,(H,22,23)(H4,17,18,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	43	-10.4	n/a	n/a	n/a	n/a	n/a	8.1	37
Pfizer					Assay Description Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...				J Med Chem 50: 2341-51 (2007) Article DOI: 10.1021/jm061066t BindingDB Entry DOI: 10.7270/Q27S7M18
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