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SMILES: COc1cc(OC)cc(c1)C#Cc1nn(C2C[C@@H](CO)N(C2)C(=O)C=C)c2ncnc(N)c12

InChI Key: InChIKey=FJYGEUHEYMHEHG-LYKKTTPLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 161415   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM161415
PNG
(US9108973, 28)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2C[C@@H](CO)N(C2)C(=O)C=C)c2ncnc(N)c12 |r|
Show InChI InChI=1S/C23H24N6O4/c1-4-20(31)28-11-15(9-16(28)12-30)29-23-21(22(24)25-13-26-23)19(27-29)6-5-14-7-17(32-2)10-18(8-14)33-3/h4,7-8,10,13,15-16,30H,1,9,11-12H2,2-3H3,(H2,24,25,26)/t15?,16-/m0/s1
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Similars
US Patent
n/an/a 3.70n/an/an/an/a7.525



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...

US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair