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SMILES: COc1cc(OC)cc(c1)C#CC1=CC([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12

InChI Key: InChIKey=MWPCSIXYMDVXLJ-HDDVOKPOSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 161425   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (Human))		BDBM161425
PNG
(US9108973, 38)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CC([C@H]2CCN(C2)C(=O)\C=C\CN(C)C)c2ncnc(N)c12 |r,t:13|
Show InChI InChI=1S/C27H31N5O3/c1-31(2)10-5-6-24(33)32-11-9-20(16-32)23-14-19(25-26(23)29-17-30-27(25)28)8-7-18-12-21(34-3)15-22(13-18)35-4/h5-6,12-15,17,20,23H,9-11,16H2,1-4H3,(H2,28,29,30)/b6-5+/t20-,23?/m0/s1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 4.70n/an/an/an/a7.525



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...

US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair