null

SMILES: COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12

InChI Key: InChIKey=BXDAOBOXMMBNTH-AATRIKPKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 161444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161444 (US10124003, Ex. Compound 57 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C26H30N6O3/c1-17(2)28-9-5-6-23(33)31-14-20(15-31)32-13-19(24-25(27)29-16-30-26(24)32)8-7-18-10-21(34-3)12-22(11-18)35-4/h5-6,10-13,16-17,20,28H,9,14-15H2,1-4H3,(H2,27,29,30)/b6-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.5	25
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US9108973 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HJV
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161444 (US10124003, Ex. Compound 57 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C26H30N6O3/c1-17(2)28-9-5-6-23(33)31-14-20(15-31)32-13-19(24-25(27)29-16-30-26(24)32)8-7-18-10-21(34-3)12-22(11-18)35-4/h5-6,10-13,16-17,20,28H,9,14-15H2,1-4H3,(H2,27,29,30)/b6-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10894048 (2021)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161444 (US10124003, Ex. Compound 57 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C26H30N6O3/c1-17(2)28-9-5-6-23(33)31-14-20(15-31)32-13-19(24-25(27)29-16-30-26(24)32)8-7-18-10-21(34-3)12-22(11-18)35-4/h5-6,10-13,16-17,20,28H,9,14-15H2,1-4H3,(H2,27,29,30)/b6-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10835536 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM161444 (US10124003, Ex. Compound 57 | US10835536, Ex. Comp...) Show SMILES COc1cc(OC)cc(c1)C#Cc1cn(C2CN(C2)C(=O)\C=C\CNC(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C26H30N6O3/c1-17(2)28-9-5-6-23(33)31-14-20(15-31)32-13-19(24-25(27)29-16-30-26(24)32)8-7-18-10-21(34-3)12-22(11-18)35-4/h5-6,10-13,16-17,20,28H,9,14-15H2,1-4H3,(H2,27,29,30)/b6-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...				US Patent US10124003 (2018) BindingDB Entry DOI: 10.7270/Q2B27XBQ
					More data for this Ligand-Target Pair