BDBM162025 US9682991, 81

SMILES: COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCc3ccc(F)cc3)nn12

InChI Key: InChIKey=SUTTVDOHBONTLF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 162025   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM162025 (US9682991, 81) Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCc3ccc(F)cc3)nn12 Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-29-21(25-26-22(19)29)15-5-9-17(30-2)10-6-15/h3-10H,11-13H2,1-2H3,(H,24,27)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III US Patent					Assay Description The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...				US Patent US9682991 (2017) BindingDB Entry DOI: 10.7270/Q2513WCB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM162025 (US9682991, 81) Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCc3ccc(F)cc3)nn12 Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-29-21(25-26-22(19)29)15-5-9-17(30-2)10-6-15/h3-10H,11-13H2,1-2H3,(H,24,27)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III US Patent					Assay Description The biochemical assay to measure PIM-3 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...				US Patent US9682991 (2017) BindingDB Entry DOI: 10.7270/Q2513WCB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM162025 (US9682991, 81) Show SMILES COc1ccc(cc1)-c1nnc2c3OCCN(C)c3c(NCc3ccc(F)cc3)nn12 Show InChI InChI=1S/C22H21FN6O2/c1-28-11-12-31-19-18(28)20(24-13-14-3-7-16(23)8-4-14)27-29-21(25-26-22(19)29)15-5-9-17(30-2)10-6-15/h3-10H,11-13H2,1-2H3,(H,24,27)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III US Patent					Assay Description The biochemical assay to measure PIM-2 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...				US Patent US9682991 (2017) BindingDB Entry DOI: 10.7270/Q2513WCB
					More data for this Ligand-Target Pair