BDBM162053 US9682991, 49

SMILES: CN1CCOc2c1c(NC1CC3(C1)CCNCC3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1

InChI Key: InChIKey=RPPZZEBQQYSMIR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 162053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM162053 (US9682991, 49) Show SMILES CN1CCOc2c1c(NC1CC3(C1)CCNCC3)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C23H26F3N7O2/c1-32-9-10-34-18-17(32)19(28-15-12-22(13-15)5-7-27-8-6-22)31-33-20(29-30-21(18)33)14-3-2-4-16(11-14)35-23(24,25)26/h2-4,11,15,27H,5-10,12-13H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III US Patent					Assay Description The biochemical assay to measure PIM-1 activity relies on the ADP Hunter assay kit (DiscoveRx Corp., Cat. #90-0077), that determines the amount of AD...				US Patent US9682991 (2017) BindingDB Entry DOI: 10.7270/Q2513WCB
					More data for this Ligand-Target Pair