null

SMILES: OC([C@H]1CC[C@H](CC1)N1CC(C1)NC(=O)CNc1ncnc2ccc(cc12)C(F)(F)F)c1cncs1

InChI Key: InChIKey=NVAPBWYJPGRDJI-GWLCFTNTSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 163470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor-like 2 (Homo sapiens (Human))	BDBM163470 (US9062048, 99) Show SMILES OC([C@H]1CC[C@H](CC1)N1CC(C1)NC(=O)CNc1ncnc2ccc(cc12)C(F)(F)F)c1cncs1 |r,wU:5.8,2.1,(-9.61,.26,;-8.28,-.51,;-6.94,.26,;-6.94,1.8,;-5.61,2.57,;-4.28,1.8,;-4.28,.26,;-5.61,-.51,;-2.94,2.57,;-1.46,2.17,;-1.06,3.65,;-2.55,4.05,;.28,4.42,;1.61,3.65,;2.94,4.42,;1.61,2.11,;2.94,1.34,;2.94,-.2,;1.61,-.97,;1.61,-2.51,;2.94,-3.28,;4.28,-2.51,;5.61,-3.28,;6.94,-2.51,;6.94,-.97,;5.61,-.2,;4.28,-.97,;8.28,-.2,;9.61,.57,;9.05,-1.53,;7.51,1.14,;-8.28,-2.05,;-9.52,-2.96,;-9.05,-4.42,;-7.51,-4.42,;-7.03,-2.96,)| Show InChI InChI=1S/C24H27F3N6O2S/c25-24(26,27)15-3-6-19-18(7-15)23(31-12-30-19)29-9-21(34)32-16-10-33(11-16)17-4-1-14(2-5-17)22(35)20-8-28-13-36-20/h3,6-8,12-14,16-17,22,35H,1-2,4-5,9-11H2,(H,32,34)(H,29,30,31)/t14-,17+,22?	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va., USA). The THP-1 cells were grown in RPMI-16...				US Patent US9062048 (2015) BindingDB Entry DOI: 10.7270/Q2ZP44W1
					More data for this Ligand-Target Pair