BDBM163687 N'‐[(1E)‐1‐(2H‐1,3‐benzodioxol‐5‐yl)ethylidene]‐3‐hydroxynaphthalene‐2‐carbohydrazide (0179)

SMILES: C\C(=N/NC(=O)c1cc2ccccc2cc1O)c1ccc2OCOc2c1

InChI Key: InChIKey=NJYGRFRKBOTJHP-CIAFOILYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 163687   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
8-Oxoguanine DNA glycosylase-1 (OGG1) (Homo sapiens (Human))	BDBM163687 (N'‐[(1E)‐1‐(2H‐1,3R...) Show SMILES C\C(=N/NC(=O)c1cc2ccccc2cc1O)c1ccc2OCOc2c1 Show InChI InChI=1S/C20H16N2O4/c1-12(13-6-7-18-19(10-13)26-11-25-18)21-22-20(24)16-8-14-4-2-3-5-15(14)9-17(16)23/h2-10,23H,11H2,1H3,(H,22,24)/b21-12+	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.17E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair