BDBM163806 US9062070, 61::US9062070, 62

SMILES: Cc1c2COC(=O)c2ccc1C1CN2CCN(CC2CCO1)C(=O)C1CCc2nc(ccc12)-n1cnnn1

InChI Key: InChIKey=JSPLQWFEUZGCGU-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 163806   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Rattus norvegicus (Rat))	BDBM163806 (US9062070, 61 | US9062070, 62) Show SMILES Cc1c2COC(=O)c2ccc1C1CN2CCN(CC2CCO1)C(=O)C1CCc2nc(ccc12)-n1cnnn1 Show InChI InChI=1S/C27H29N7O4/c1-16-18(2-3-21-22(16)14-38-27(21)36)24-13-32-9-10-33(12-17(32)8-11-37-24)26(35)20-4-6-23-19(20)5-7-25(29-23)34-15-28-30-31-34/h2-3,5,7,15,17,20,24H,4,6,8-14H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Rattus norvegicus (Rat))	BDBM163806 (US9062070, 61 | US9062070, 62) Show SMILES Cc1c2COC(=O)c2ccc1C1CN2CCN(CC2CCO1)C(=O)C1CCc2nc(ccc12)-n1cnnn1 Show InChI InChI=1S/C27H29N7O4/c1-16-18(2-3-21-22(16)14-38-27(21)36)24-13-32-9-10-33(12-17(32)8-11-37-24)26(35)20-4-6-23-19(20)5-7-25(29-23)34-15-28-30-31-34/h2-3,5,7,15,17,20,24H,4,6,8-14H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Rattus norvegicus (Rat))	BDBM163806 (US9062070, 61 | US9062070, 62) Show SMILES Cc1c2COC(=O)c2ccc1C1CN2CCN(CC2CCO1)C(=O)C1CCc2nc(ccc12)-n1cnnn1 Show InChI InChI=1S/C27H29N7O4/c1-16-18(2-3-21-22(16)14-38-27(21)36)24-13-32-9-10-33(12-17(32)8-11-37-24)26(35)20-4-6-23-19(20)5-7-25(29-23)34-15-28-30-31-34/h2-3,5,7,15,17,20,24H,4,6,8-14H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...				US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Rattus norvegicus (Rat))	BDBM163806 (US9062070, 61 | US9062070, 62) Show SMILES Cc1c2COC(=O)c2ccc1C1CN2CCN(CC2CCO1)C(=O)C1CCc2nc(ccc12)-n1cnnn1 Show InChI InChI=1S/C27H29N7O4/c1-16-18(2-3-21-22(16)14-38-27(21)36)24-13-32-9-10-33(12-17(32)8-11-37-24)26(35)20-4-6-23-19(20)5-7-25(29-23)34-15-28-30-31-34/h2-3,5,7,15,17,20,24H,4,6,8-14H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...				US Patent US9062070 (2015) BindingDB Entry DOI: 10.7270/Q2WQ02JX
					More data for this Ligand-Target Pair