BDBM164229 US9688615, 40

SMILES: CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C

InChI Key: InChIKey=MCTBWIJBNPDDGO-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 164229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated calcium channel subunit alpha Cav2.2 (Homo sapiens (Human))	BDBM164229 (US9688615, 40) Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C Show InChI InChI=1S/C16H17F6N3O2/c1-14(2,3)27-13(26)25(4)7-11-23-10-6-8(15(17,18)19)5-9(12(10)24-11)16(20,21)22/h5-6H,7H2,1-4H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-gated calcium channel subunit alpha Cav2.2 (Homo sapiens (Human))	BDBM164229 (US9688615, 40) Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C Show InChI InChI=1S/C16H17F6N3O2/c1-14(2,3)27-13(26)25(4)7-11-23-10-6-8(15(17,18)19)5-9(12(10)24-11)16(20,21)22/h5-6H,7H2,1-4H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-gated T-type calcium channel (Homo sapiens (Human))	BDBM164229 (US9688615, 40) Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C Show InChI InChI=1S/C16H17F6N3O2/c1-14(2,3)27-13(26)25(4)7-11-23-10-6-8(15(17,18)19)5-9(12(10)24-11)16(20,21)22/h5-6H,7H2,1-4H3,(H,23,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Calcium channel (Type L) (Homo sapiens (Human))	BDBM164229 (US9688615, 40) Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C Show InChI InChI=1S/C16H17F6N3O2/c1-14(2,3)27-13(26)25(4)7-11-23-10-6-8(15(17,18)19)5-9(12(10)24-11)16(20,21)22/h5-6H,7H2,1-4H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	7.4	n/a
SRMLSC US Patent					Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM164229 (US9688615, 40) Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C Show InChI InChI=1S/C16H17F6N3O2/c1-14(2,3)27-13(26)25(4)7-11-23-10-6-8(15(17,18)19)5-9(12(10)24-11)16(20,21)22/h5-6H,7H2,1-4H3,(H,23,24)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Calcium channel (Type L) (Homo sapiens (Human))	BDBM164229 (US9688615, 40) Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C Show InChI InChI=1S/C16H17F6N3O2/c1-14(2,3)27-13(26)25(4)7-11-23-10-6-8(15(17,18)19)5-9(12(10)24-11)16(20,21)22/h5-6H,7H2,1-4H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
SRMLSC US Patent					Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM164229 (US9688615, 40) Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C Show InChI InChI=1S/C16H17F6N3O2/c1-14(2,3)27-13(26)25(4)7-11-23-10-6-8(15(17,18)19)5-9(12(10)24-11)16(20,21)22/h5-6H,7H2,1-4H3,(H,23,24)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair