null

SMILES: CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=AYFKQFUWSLEACG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 164335   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent N-type calcium channel subunit alpha-1B (Homo sapiens (Human))	BDBM164335 (US9688615, 146) Show SMILES CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H20F6N4O2/c1-16(2,30)9-28-13-6-11(18(22,23)24)10(17(19,20)21)5-12(13)26-14(28)8-27-4-3-25-7-15(27)29/h5-6,25,30H,3-4,7-9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B (Homo sapiens (Human))	BDBM164335 (US9688615, 146) Show SMILES CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H20F6N4O2/c1-16(2,30)9-28-13-6-11(18(22,23)24)10(17(19,20)21)5-12(13)26-14(28)8-27-4-3-25-7-15(27)29/h5-6,25,30H,3-4,7-9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Homo sapiens (Human))	BDBM164335 (US9688615, 146) Show SMILES CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H20F6N4O2/c1-16(2,30)9-28-13-6-11(18(22,23)24)10(17(19,20)21)5-12(13)26-14(28)8-27-4-3-25-7-15(27)29/h5-6,25,30H,3-4,7-9H2,1-2H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Homo sapiens (Human))	BDBM164335 (US9688615, 146) Show SMILES CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H20F6N4O2/c1-16(2,30)9-28-13-6-11(18(22,23)24)10(17(19,20)21)5-12(13)26-14(28)8-27-4-3-25-7-15(27)29/h5-6,25,30H,3-4,7-9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
SRMLSC US Patent					Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM164335 (US9688615, 146) Show SMILES CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H20F6N4O2/c1-16(2,30)9-28-13-6-11(18(22,23)24)10(17(19,20)21)5-12(13)26-14(28)8-27-4-3-25-7-15(27)29/h5-6,25,30H,3-4,7-9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Homo sapiens (Human))	BDBM164335 (US9688615, 146) Show SMILES CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H20F6N4O2/c1-16(2,30)9-28-13-6-11(18(22,23)24)10(17(19,20)21)5-12(13)26-14(28)8-27-4-3-25-7-15(27)29/h5-6,25,30H,3-4,7-9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
SRMLSC US Patent					Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM164335 (US9688615, 146) Show SMILES CC(C)(O)Cn1c(CN2CCNCC2=O)nc2cc(c(cc12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H20F6N4O2/c1-16(2,30)9-28-13-6-11(18(22,23)24)10(17(19,20)21)5-12(13)26-14(28)8-27-4-3-25-7-15(27)29/h5-6,25,30H,3-4,7-9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair