BDBM164360 US9688615, 171

SMILES: NC1(Cc2nc3cc(cc(c3[nH]2)C(F)(F)F)C(F)(F)F)CCCCC1

InChI Key: InChIKey=WZZJBESTVLOCMV-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 164360   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated calcium channel subunit alpha Cav2.2 (Homo sapiens (Human))	BDBM164360 (US9688615, 171) Show SMILES NC1(Cc2nc3cc(cc(c3[nH]2)C(F)(F)F)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C16H17F6N3/c17-15(18,19)9-6-10(16(20,21)22)13-11(7-9)24-12(25-13)8-14(23)4-2-1-3-5-14/h6-7H,1-5,8,23H2,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-gated calcium channel subunit alpha Cav2.2 (Homo sapiens (Human))	BDBM164360 (US9688615, 171) Show SMILES NC1(Cc2nc3cc(cc(c3[nH]2)C(F)(F)F)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C16H17F6N3/c17-15(18,19)9-6-10(16(20,21)22)13-11(7-9)24-12(25-13)8-14(23)4-2-1-3-5-14/h6-7H,1-5,8,23H2,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-gated T-type calcium channel (Homo sapiens (Human))	BDBM164360 (US9688615, 171) Show SMILES NC1(Cc2nc3cc(cc(c3[nH]2)C(F)(F)F)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C16H17F6N3/c17-15(18,19)9-6-10(16(20,21)22)13-11(7-9)24-12(25-13)8-14(23)4-2-1-3-5-14/h6-7H,1-5,8,23H2,(H,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Calcium channel (Type L) (Homo sapiens (Human))	BDBM164360 (US9688615, 171) Show SMILES NC1(Cc2nc3cc(cc(c3[nH]2)C(F)(F)F)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C16H17F6N3/c17-15(18,19)9-6-10(16(20,21)22)13-11(7-9)24-12(25-13)8-14(23)4-2-1-3-5-14/h6-7H,1-5,8,23H2,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.65E+3	n/a	n/a	n/a	n/a	7.4	n/a
SRMLSC US Patent					Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM164360 (US9688615, 171) Show SMILES NC1(Cc2nc3cc(cc(c3[nH]2)C(F)(F)F)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C16H17F6N3/c17-15(18,19)9-6-10(16(20,21)22)13-11(7-9)24-12(25-13)8-14(23)4-2-1-3-5-14/h6-7H,1-5,8,23H2,(H,24,25)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Calcium channel (Type L) (Homo sapiens (Human))	BDBM164360 (US9688615, 171) Show SMILES NC1(Cc2nc3cc(cc(c3[nH]2)C(F)(F)F)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C16H17F6N3/c17-15(18,19)9-6-10(16(20,21)22)13-11(7-9)24-12(25-13)8-14(23)4-2-1-3-5-14/h6-7H,1-5,8,23H2,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
SRMLSC US Patent					Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM164360 (US9688615, 171) Show SMILES NC1(Cc2nc3cc(cc(c3[nH]2)C(F)(F)F)C(F)(F)F)CCCCC1 Show InChI InChI=1S/C16H17F6N3/c17-15(18,19)9-6-10(16(20,21)22)13-11(7-9)24-12(25-13)8-14(23)4-2-1-3-5-14/h6-7H,1-5,8,23H2,(H,24,25)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair