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SMILES: Fc1cc(F)cc(c1)-c1cnc2onc(c2c1)C(F)(F)c1ccc2ncccc2c1

InChI Key: InChIKey=JRLKVVBERFUKCG-UHFFFAOYSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 164492   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM164492
PNG
(US9066954, 439)
Show SMILES Fc1cc(F)cc(c1)-c1cnc2onc(c2c1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C22H11F4N3O/c23-16-7-13(8-17(24)10-16)14-9-18-20(29-30-21(18)28-11-14)22(25,26)15-3-4-19-12(6-15)2-1-5-27-19/h1-11H
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Similars
US Patent
 253 -9.05n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...

US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair