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BDBM16517 2-(2-chlorophenyl)-6-[(2-fluorophenyl)sulfanyl]-2,3-dihydropyridazin-3-one::2-arylpyridazin-3-one, 20

SMILES: Fc1ccccc1Sc1ccc(=O)n(n1)-c1ccccc1Cl

InChI Key: InChIKey=QQEWAIUOEYEOLT-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16517   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP Kinase p38 beta


(Mus musculus (mouse))
BDBM16517
PNG
(2-(2-chlorophenyl)-6-[(2-fluorophenyl)sulfanyl]-2,...)
Show SMILES Fc1ccccc1Sc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C16H10ClFN2OS/c17-11-5-1-3-7-13(11)20-16(21)10-9-15(19-20)22-14-8-4-2-6-12(14)18/h1-10H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...


Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM16517
PNG
(2-(2-chlorophenyl)-6-[(2-fluorophenyl)sulfanyl]-2,...)
Show SMILES Fc1ccccc1Sc1ccc(=O)n(n1)-c1ccccc1Cl
Show InChI InChI=1S/C16H10ClFN2OS/c17-11-5-1-3-7-13(11)20-16(21)10-9-15(19-20)22-14-8-4-2-6-12(14)18/h1-10H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 140n/an/an/an/a7.030



Merck Research Laboratories



Assay Description
The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...


Bioorg Med Chem Lett 16: 5809-13 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.074
BindingDB Entry DOI: 10.7270/Q28P5XSC
More data for this
Ligand-Target Pair