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SMILES: Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cc(F)cc(c2)C(F)(F)F)c1

InChI Key: InChIKey=UIXJCGDDTYZBHF-IBGZPJMESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16568   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D]


(Homo sapiens (Human))		BDBM16568
PNG
((2S)-1-[5-fluoro-3-(trifluoromethyl)phenyl]-3-{[5-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2cc(F)cc(c2)C(F)(F)F)c1 |r|
Show InChI InChI=1S/C23H20F4N4O/c1-13-21-8-15(2-3-22(21)31-30-13)16-7-20(11-29-10-16)32-12-19(28)6-14-4-17(23(25,26)27)9-18(24)5-14/h2-5,7-11,19H,6,12,28H2,1H3,(H,30,31)/t19-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

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PC cid
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UniChem

Similars
Article
PubMed
n/an/a 13.3n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...

J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair