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SMILES: Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc3OC(F)(F)C(F)(F)Oc3c2)c1

InChI Key: InChIKey=XGYHYTSMABCFHU-KRWDZBQOSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16578   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D]


(Homo sapiens (Human))		BDBM16578
PNG
((2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc3OC(F)(F)C(F)(F)Oc3c2)c1 |r|
Show InChI InChI=1S/C24H20F4N4O3/c1-13-19-9-15(3-4-20(19)32-31-13)16-8-18(11-30-10-16)33-12-17(29)6-14-2-5-21-22(7-14)35-24(27,28)23(25,26)34-21/h2-5,7-11,17H,6,12,29H2,1H3,(H,31,32)/t17-/m0/s1
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MMDB

UniProtKB/SwissProt

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UniChem

Similars
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...

J Med Chem 50: 2990-3003 (2007)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q24X562F
More data for this
Ligand-Target Pair