null

SMILES: N[C@H](COc1cncc(c1)-c1cc2cn[nH]c2cn1)Cc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=OZPLURSGGRWIKB-KRWDZBQOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16585   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-dependent protein kinase catalytic subunit alpha (Bos taurus (bovine))	BDBM16585 ((2S)-1-{[5-(1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin...) Show SMILES N[C@H](COc1cncc(c1)-c1cc2cn[nH]c2cn1)Cc1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)16-3-1-2-13(4-16)5-17(25)12-30-18-6-14(8-26-10-18)19-7-15-9-28-29-20(15)11-27-19/h1-4,6-11,17H,5,12,25H2,(H,28,29)/t17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				J Med Chem 50: 2990-3003 (2007) Article DOI: 10.1021/jm0701019 BindingDB Entry DOI: 10.7270/Q24X562F
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D] (Homo sapiens (Human))	BDBM16585 ((2S)-1-{[5-(1H-pyrazolo[3,4-c]pyridin-5-yl)pyridin...) Show SMILES N[C@H](COc1cncc(c1)-c1cc2cn[nH]c2cn1)Cc1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)16-3-1-2-13(4-16)5-17(25)12-30-18-6-14(8-26-10-18)19-7-15-9-28-29-20(15)11-27-19/h1-4,6-11,17H,5,12,25H2,(H,28,29)/t17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				J Med Chem 50: 2990-3003 (2007) Article DOI: 10.1021/jm0701019 BindingDB Entry DOI: 10.7270/Q24X562F
					More data for this Ligand-Target Pair