BDBM166098 US9067937, 42

SMILES: CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cn[nH]c1)C(C)=O

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 166098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM166098 (US9067937, 42) Show SMILES CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cn[nH]c1)C(C)=O |r,wU:4.3,wD:7.10,(-4.82,5,;-3.48,4.23,;-2.15,5,;-3.48,2.69,;-2.15,1.93,;-.82,2.69,;.52,1.93,;.52,.38,;-.82,-.38,;-2.15,.38,;1.85,-.38,;1.85,-1.93,;3.19,-2.69,;3.19,-4.23,;1.85,-5,;.52,-4.23,;-.82,-5,;-2.15,-4.23,;-2.15,-2.69,;-.82,-1.93,;.52,-2.69,;-3.48,-1.93,;-4.95,-2.4,;-5.85,-1.15,;-4.95,.09,;-3.48,-.38,;4.52,-1.93,;5.85,-2.69,;4.52,-.38,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	25
OncoTherapy Science, Inc. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9067937 (2015) BindingDB Entry DOI: 10.7270/Q2BR8QX4
					More data for this Ligand-Target Pair