BDBM167055 US9073876, 141::US9732093, Compound 141

SMILES: Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(ncn2)C2CC2)c1F

InChI Key: InChIKey=UAJBCRAPBRCHLL-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 167055   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM167055 (US9073876, 141 | US9732093, Compound 141) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(ncn2)C2CC2)c1F Show InChI InChI=1S/C21H20FN5O/c22-20-15(17-9-25-18(23)10-24-17)7-6-14(12-2-1-3-12)21(20)28-19-8-16(13-4-5-13)26-11-27-19/h6-13H,1-5H2,(H2,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9073876 (2015) BindingDB Entry DOI: 10.7270/Q28S4NPC
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167055 (US9073876, 141 | US9732093, Compound 141) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(ncn2)C2CC2)c1F Show InChI InChI=1S/C21H20FN5O/c22-20-15(17-9-25-18(23)10-24-17)7-6-14(12-2-1-3-12)21(20)28-19-8-16(13-4-5-13)26-11-27-19/h6-13H,1-5H2,(H2,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167055 (US9073876, 141 | US9732093, Compound 141) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(ncn2)C2CC2)c1F Show InChI InChI=1S/C21H20FN5O/c22-20-15(17-9-25-18(23)10-24-17)7-6-14(12-2-1-3-12)21(20)28-19-8-16(13-4-5-13)26-11-27-19/h6-13H,1-5H2,(H2,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair