BDBM167440 US9073906, 122

SMILES: NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2

InChI Key: InChIKey=HUZDSKQBMBUYIL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 167440   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human))	BDBM167440 (US9073906, 122) Show SMILES NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 |TLB:1:3:6:9.32.33,10:9:6:3.4.8,10:9:3.34.8:6.5.33,THB:4:3:9:6.5.33,4:5:9:3.34.8,34:3:6:9.32.33,34:32:6:3.4.8,(9.32,3.3,;8.55,1.97,;9.32,.63,;7.01,1.97,;6.61,3.45,;5.13,3.85,;4.04,2.77,;4.44,1.28,;5.93,.88,;4.12,-.77,;2.79,-1.54,;1.46,-.77,;1.46,.77,;.12,-1.54,;-1.21,-.77,;-.87,.73,;-1.83,1.93,;-3.37,1.93,;-4.33,.73,;-3.99,-.77,;-5.32,-1.54,;-6.65,-.77,;-6.65,.77,;-7.99,-1.54,;-7.99,-3.08,;-9.32,-3.85,;-6.65,-3.85,;-5.32,-3.08,;-3.99,-3.85,;-2.6,-1.44,;-3.37,-2.77,;-1.83,-2.77,;5.31,.21,;4.7,2.53,;6.64,-.13,)| Show InChI InChI=1S/C23H29Cl3N4O4S/c24-16-7-17(25)21(18(26)8-16)30-4-2-1-3-29(35(30,33)34)12-19(31)28-20-14-5-13-6-15(20)11-23(9-13,10-14)22(27)32/h7-8,13-15,20H,1-6,9-12H2,(H2,27,32)(H,28,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY US Patent					Assay Description The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...				US Patent US9073906 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MFB
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM167440 (US9073906, 122) Show SMILES NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 |TLB:1:3:6:9.32.33,10:9:6:3.4.8,10:9:3.34.8:6.5.33,THB:4:3:9:6.5.33,4:5:9:3.34.8,34:3:6:9.32.33,34:32:6:3.4.8,(9.32,3.3,;8.55,1.97,;9.32,.63,;7.01,1.97,;6.61,3.45,;5.13,3.85,;4.04,2.77,;4.44,1.28,;5.93,.88,;4.12,-.77,;2.79,-1.54,;1.46,-.77,;1.46,.77,;.12,-1.54,;-1.21,-.77,;-.87,.73,;-1.83,1.93,;-3.37,1.93,;-4.33,.73,;-3.99,-.77,;-5.32,-1.54,;-6.65,-.77,;-6.65,.77,;-7.99,-1.54,;-7.99,-3.08,;-9.32,-3.85,;-6.65,-3.85,;-5.32,-3.08,;-3.99,-3.85,;-2.6,-1.44,;-3.37,-2.77,;-1.83,-2.77,;5.31,.21,;4.7,2.53,;6.64,-.13,)| Show InChI InChI=1S/C23H29Cl3N4O4S/c24-16-7-17(25)21(18(26)8-16)30-4-2-1-3-29(35(30,33)34)12-19(31)28-20-14-5-13-6-15(20)11-23(9-13,10-14)22(27)32/h7-8,13-15,20H,1-6,9-12H2,(H2,27,32)(H,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY US Patent					Assay Description The in vitro inhibitory activities of the novel compounds to human 11β-HSD1 were evaluated in accordance with homogenous time-resolved fluoresce...				US Patent US9073906 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MFB
					More data for this Ligand-Target Pair