BDBM168239 US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 67)

SMILES: Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C

InChI Key: InChIKey=JYJWZHLMBPNEJV-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 168239   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM168239 (US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylami...) Show SMILES Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C Show InChI InChI=1S/C14H15N5O2/c1-8-6-9(17-10-4-5-15-7-16-10)13(21)19-11(8)12(20)18-14(19,2)3/h4-7H,1-3H3,(H,18,20)(H,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM168239 (US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylami...) Show SMILES Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C Show InChI InChI=1S/C14H15N5O2/c1-8-6-9(17-10-4-5-15-7-16-10)13(21)19-11(8)12(20)18-14(19,2)3/h4-7H,1-3H3,(H,18,20)(H,15,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM168239 (US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylami...) Show SMILES Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C Show InChI InChI=1S/C14H15N5O2/c1-8-6-9(17-10-4-5-15-7-16-10)13(21)19-11(8)12(20)18-14(19,2)3/h4-7H,1-3H3,(H,18,20)(H,15,16,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States. Curated by ChEMBL					Assay Description Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...				J Med Chem 61: 3516-3540 (2018) Article DOI: 10.1021/acs.jmedchem.7b01795 BindingDB Entry DOI: 10.7270/Q2NC63PS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2 (Homo sapiens (Human))	BDBM168239 (US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylami...) Show SMILES Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C Show InChI InChI=1S/C14H15N5O2/c1-8-6-9(17-10-4-5-15-7-16-10)13(21)19-11(8)12(20)18-14(19,2)3/h4-7H,1-3H3,(H,18,20)(H,15,16,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States. Curated by ChEMBL					Assay Description Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assay				J Med Chem 61: 3516-3540 (2018) Article DOI: 10.1021/acs.jmedchem.7b01795 BindingDB Entry DOI: 10.7270/Q2NC63PS
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM168239 (US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylami...) Show SMILES Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C Show InChI InChI=1S/C14H15N5O2/c1-8-6-9(17-10-4-5-15-7-16-10)13(21)19-11(8)12(20)18-14(19,2)3/h4-7H,1-3H3,(H,18,20)(H,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States. Curated by ChEMBL					Assay Description Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...				J Med Chem 61: 3516-3540 (2018) Article DOI: 10.1021/acs.jmedchem.7b01795 BindingDB Entry DOI: 10.7270/Q2NC63PS
					More data for this Ligand-Target Pair