BDBM168282 US9669031, 110 8-chloro-4′,4′-difluoro-6-(pyrimidin-4-ylamino)spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-1,5-dione hydrochloride (Cpd. No. 110)

SMILES: FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21

InChI Key: InChIKey=GGICRDSGZDXVSN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 168282   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM168282 (US9669031, 110 8-chloro-4′,4′-difluoro...) Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21 Show InChI InChI=1S/C16H14ClF2N5O2/c17-9-7-10(22-11-1-6-20-8-21-11)14(26)24-12(9)13(25)23-16(24)4-2-15(18,19)3-5-16/h1,6-8H,2-5H2,(H,23,25)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM168282 (US9669031, 110 8-chloro-4′,4′-difluoro...) Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3ccncn3)c(=O)n21 Show InChI InChI=1S/C16H14ClF2N5O2/c17-9-7-10(22-11-1-6-20-8-21-11)14(26)24-12(9)13(25)23-16(24)4-2-15(18,19)3-5-16/h1,6-8H,2-5H2,(H,23,25)(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair