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SMILES: CC1(C)NC(=O)c2c(Cl)cc(Nc3ncnc4ccncc34)c(=O)n12

InChI Key: InChIKey=IOKLADYJDHRJIK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168297   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168297
PNG
(US9669031, 124 8-chloro-3,3-dimethyl-6-(pyrido[4,3...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ncnc4ccncc34)c(=O)n12
Show InChI InChI=1S/C16H13ClN6O2/c1-16(2)22-14(24)12-9(17)5-11(15(25)23(12)16)21-13-8-6-18-4-3-10(8)19-7-20-13/h3-7H,1-2H3,(H,22,24)(H,19,20,21)
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MMDB

KEGG

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PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair