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SMILES: Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCN(CC#N)CC1

InChI Key: InChIKey=YGUAWOGUKVTWBA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168325   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168325
PNG
(US9669031, 160 2-(8-chloro-1,5-dioxo-6-(pyrimidin-...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCN(CC#N)CC1
Show InChI InChI=1S/C17H16ClN7O2/c18-11-9-12(22-13-1-5-20-10-21-13)16(27)25-14(11)15(26)23-17(25)2-6-24(7-3-17)8-4-19/h1,5,9-10H,2-3,6-8H2,(H,23,26)(H,20,21,22)
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KEGG

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PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair