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SMILES: Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCC(O)CC1

InChI Key: InChIKey=KFNYRNPXQICPOT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168355   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168355
PNG
(US9669031, 206 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCC(O)CC1 |(4.87,-20.91,;4.87,-22.45,;3.54,-23.22,;3.54,-24.76,;2.21,-25.53,;.89,-24.76,;-.45,-25.53,;-1.78,-24.76,;-3.11,-25.53,;-1.78,-23.22,;-.45,-22.45,;.89,-23.22,;4.87,-25.53,;4.87,-27.07,;6.21,-24.76,;6.21,-23.22,;7.67,-22.74,;8.44,-21.41,;8.58,-23.99,;7.67,-25.23,;6.58,-26.32,;6.98,-27.81,;8.47,-28.21,;8.87,-29.7,;9.56,-27.12,;9.16,-25.63,)|
Show InChI InChI=1S/C17H20N6O3/c1-9-6-11(21-13-7-12(18)19-8-20-13)16(26)23-14(9)15(25)22-17(23)4-2-10(24)3-5-17/h6-8,10,24H,2-5H2,1H3,(H,22,25)(H3,18,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair