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SMILES: COc1cncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)F)CC3)n2c1=O

InChI Key: InChIKey=JCPXEYZKEMMQKA-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168373   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168373
PNG
(US9669031, 230 1′-(2,2-difluoroethyl)-6-((5-...)
Show SMILES COc1cncnc1Nc1cc(C)c2C(=O)NC3(CCN(CC(F)F)CC3)n2c1=O
Show InChI InChI=1S/C19H22F2N6O3/c1-11-7-12(24-16-13(30-2)8-22-10-23-16)18(29)27-15(11)17(28)25-19(27)3-5-26(6-4-19)9-14(20)21/h7-8,10,14H,3-6,9H2,1-2H3,(H,25,28)(H,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair