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SMILES: Cc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCN(CC(F)(F)F)CC1

InChI Key: InChIKey=CFFSDCXVOIUZKT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 168375   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM168375
PNG
(US9669031, 232 6-((6-aminopyrimidin-4-yl)amino)-8-...)
Show SMILES Cc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C22H24F3N7O3/c1-12-8-14(28-15-9-16(27-11-26-15)29-18(33)13-2-3-13)20(35)32-17(12)19(34)30-21(32)4-6-31(7-5-21)10-22(23,24)25/h8-9,11,13H,2-7,10H2,1H3,(H,30,34)(H2,26,27,28,29,33)
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MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/a25



eFFECTOR THERAPEUTICS, INC.

US Patent


Assay Description
Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...

US Patent US9669031 (2017)


BindingDB Entry DOI: 10.7270/Q26Q1VDT
More data for this
Ligand-Target Pair