BDBM168706 US9079866, 83::US9745328, Compound 83::US9884878, Compound 83

SMILES: C[C@H](NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)[C@@H](O)c1ccccc1

InChI Key: InChIKey=ILKBYOWTWQVVFF-IVCQMTBJSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 168706   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM168706 (US9079866, 83 | US9745328, Compound 83 | US9884878...) Show SMILES C[C@H](NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)[C@@H](O)c1ccccc1 |r| Show InChI InChI=1S/C25H23FN4O3S/c1-16(25(31)17-7-3-2-4-8-17)30-34(32,33)23-10-6-5-9-19(23)18-11-12-20(21(26)13-18)22-14-29-24(27)15-28-22/h2-16,25,30-31H,1H3,(H2,27,29)/t16-,25+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9079866 (2015) BindingDB Entry DOI: 10.7270/Q2FF3R3Q
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168706 (US9079866, 83 | US9745328, Compound 83 | US9884878...) Show SMILES C[C@H](NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)[C@@H](O)c1ccccc1 |r| Show InChI InChI=1S/C25H23FN4O3S/c1-16(25(31)17-7-3-2-4-8-17)30-34(32,33)23-10-6-5-9-19(23)18-11-12-20(21(26)13-18)22-14-29-24(27)15-28-22/h2-16,25,30-31H,1H3,(H2,27,29)/t16-,25+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM168706 (US9079866, 83 | US9745328, Compound 83 | US9884878...) Show SMILES C[C@H](NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)[C@@H](O)c1ccccc1 |r| Show InChI InChI=1S/C25H23FN4O3S/c1-16(25(31)17-7-3-2-4-8-17)30-34(32,33)23-10-6-5-9-19(23)18-11-12-20(21(26)13-18)22-14-29-24(27)15-28-22/h2-16,25,30-31H,1H3,(H2,27,29)/t16-,25+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9884878 (2018) BindingDB Entry DOI: 10.7270/Q2R78H8P
					More data for this Ligand-Target Pair