BDBM168743 US9079866, 133::US9745328, Compound 133::US9884878, Compound 133

SMILES: Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NCCCCCCO

InChI Key: InChIKey=ZNBPLBRJRRTNAD-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 168743   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM168743 (US9079866, 133 | US9745328, Compound 133 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NCCCCCCO Show InChI InChI=1S/C22H25FN4O3S/c23-19-13-16(9-10-18(19)20-14-26-22(24)15-25-20)17-7-3-4-8-21(17)31(29,30)27-11-5-1-2-6-12-28/h3-4,7-10,13-15,27-28H,1-2,5-6,11-12H2,(H2,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9079866 (2015) BindingDB Entry DOI: 10.7270/Q2FF3R3Q
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168743 (US9079866, 133 | US9745328, Compound 133 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NCCCCCCO Show InChI InChI=1S/C22H25FN4O3S/c23-19-13-16(9-10-18(19)20-14-26-22(24)15-25-20)17-7-3-4-8-21(17)31(29,30)27-11-5-1-2-6-12-28/h3-4,7-10,13-15,27-28H,1-2,5-6,11-12H2,(H2,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM168743 (US9079866, 133 | US9745328, Compound 133 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NCCCCCCO Show InChI InChI=1S/C22H25FN4O3S/c23-19-13-16(9-10-18(19)20-14-26-22(24)15-25-20)17-7-3-4-8-21(17)31(29,30)27-11-5-1-2-6-12-28/h3-4,7-10,13-15,27-28H,1-2,5-6,11-12H2,(H2,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9884878 (2018) BindingDB Entry DOI: 10.7270/Q2R78H8P
					More data for this Ligand-Target Pair