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SMILES: N[C@H](COc1cncc(c1)-c1ccc2[nH]c(=O)n(CC#N)c2c1)Cc1c[nH]c2ccccc12

InChI Key: InChIKey=DUWSEJSTHAHIBW-IBGZPJMESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16928   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D]


(Homo sapiens (Human))		BDBM16928
PNG
(2-(6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2[nH]c(=O)n(CC#N)c2c1)Cc1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C25H22N6O2/c26-7-8-31-24-11-16(5-6-23(24)30-25(31)32)17-10-20(14-28-12-17)33-15-19(27)9-18-13-29-22-4-2-1-3-21(18)22/h1-6,10-14,19,29H,8-9,15,27H2,(H,30,32)/t19-/m0/s1
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 405n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...

Bioorg Med Chem Lett 16: 3424-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.005
BindingDB Entry DOI: 10.7270/Q2K072JJ
More data for this
Ligand-Target Pair